Toronto is the largest city in Canada and the provincial capital of Ontario. It previously consisted of five separate cities (Etobicoke, North York, East York, Scarborough, and downtown Toronto) before they amalgamated into one "megacity" in 1998.
In the context of The Handmaid's Tale TV series, a consulate for the US government-in-exile is established there, along with a residential district known as "Little America", made up of refugees from Gilead including former Guardians, Handmaids, Marthas, children, Unwomen, and others etc.
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